This article was inspired by a Subscriber’s recent comment in the article entitled, REPOST: Ivermectin May Defeat Cancer and Other Common Chronic Diseases of Aging, where he shared his positive and most surprising “side effect:”
I’m not a doctor. I’m a brain tumor survivor. This is just my personal observation and lay opinion, so please don’t come after me. Aren’t most forms of disease related to or caused by parasites and fungus? I was having this conversation with my neurosurgeon recently and he even said that there maybe be a correlation between tumors and parasites as well as fungus as it pertains to the cause of the brain tumor I had. I had the brain tumor successfully removed 4 and a half years ago. The way ivermectin has been demonized by the FDA, government officials, MSM and others, it’s my firm belief that ivermectin maybe one of the most effective treatments that we have to combat the diseases that we are experiencing
Ivermectin appears to be the most generally effective drug in the world, and it's a generic thanks to the generosity of its inventor...That's why Pharma hates it....
Headaches often due to gut issues like constipation or over toxicity - as in if you go off tea / caffeine and body starts gettng rid of the toxins, they build up and you get headaches unless you take a cup of tea........
I spoke to a new friend about this. He's had a glioblastoma for years. One of his dogs is covered in lumps, the other has digestive issues, needs to be fed pumpkin for constipation. Each can be caused by parasites. I suggested he try ivermectin alone or with fenbendazole. What does he have to lose? His little buddy in his head? Unfortunately he's trapped by his faith. Faith that somehow the allopathic doctors that haven't helped him yet eventually will. And that if his faith slips, if he tries an alternative treatment, he'll have sinned against the Almighty MD's.
Both my parents died of cancer, a year apart, 23 years ago. I can't help but wonder, was it parasites from the small house dogs they had later in life? Would Ivermectin have saved them? I'll never know, but I suspect we will all learn of successful home treatment and cures of cancer in the near future, through association and word of mouth anyway.
Allopathic procedures are necessary in emergency situations, but for the most part I steer clear of hospitals and allopathic medicine. I have the good fortune of working with a phenomenal naturopathic care provider
Many tumours have been found to be sacs of parasite eggs; and even MS is parasites. Diabetes caused by fluke parasite which lives on insulin; go to the GP they'll feed the parasites and never deal with the issue; Dr June Levy proved these points above
I'm starting to think that this threat of masking and more Injections is just that, an empty threat, to keep people focused on that while other far more damaging things go on.
Remember, always watch the Other Hand of the Magician.
If the world knew for a fact, that 9-11 and Lahaina were both conducted, wilfully, by the same ilk, how would Americans respond?
New Injections are going to be coming out continually.
"Covid" (for those gullible enough to even think that it's real) is the first virus in human history that can only be cured by a never-ending string of government approved Injections.
Among the reasons why anyone with basis research skills could easily identify that this was a PSYOP starting the day it was hatched, is because of A, the status of the "vaccine" INDUSTRY, and B, the deaths, ill-health, disease, ailments, et al. that vaccines have caused over the decades.
Similar for Lahaina, we've seen a similar operation before, it was called 9-11, but how many people recognize that that too was a PSYOP and a deliberately played card by the exact same people bringing us this full-fledged demonization of the world today.
Especially with Lahaina, aka 9-11 Hawaiian Version, going on.
They're out in the open now, no doubt laughing their heads off behind closed doors as to how they can come straight out and put their intentions out there and online, fully open for anyone to see, and see that the vast majority of people still don't have a clue.
I'm not sure about most people not having a clue any more though; it's massively different to what it was even a few months ago; HUGE awakeniing; although evenone prob sick and tired of that word, it's really happening and frankly their arrogance, especially with Winfrey coming out lookiing for donations for God's sake, completely ignorant of the fact they're just opening the trap door for themselves - it's going to get mad, definitely as the worm turns and they writhe and twist, but we just have to hold on and know God is there, with Russia, Africa and China, and Nature, to briing a final close to satan's vile wrretched foul debacle after the last hundred years war
Everything is absolutely fascinating to watch unfold. Those behind it all are playing the public like a master violinist plays a Stradivarius. It truly is masterful to behold. I find myself SMH perpetually at how well it all works for them, all but seemlessly. Meanwhile, we're tinkering with "yesterday's news."
PS ... my thought is that lockdowns won't happen for that reason. That could very well be part of their play. Get everyone hyped on that, everyone gets ready to dodge that "right cross," but then they get blind-sided by the left hook.
These people behind this as so predictable if one knows what to look for, and it's not difficult. But first people have to know who's really behind it.
Those looking to politics for the reasons, causes, solutions in particular, are entirely lost. Their hope of ever figuring it out are slim.
I've lost so much hope from most of the writers right here on Substack that I thought might actually realize what's going on at the core. I've been testing a few of them, but some of my comments are getting deleted by them. Which says much.
Caitlin Johnstone's the most recent. She's either bought and paid for, which makes sense given that she's supposedly operating out of Austrailia given how badly they've cracked down on so many others down there for much less, or she's simply lost as well, to the point of not only being useless with her semi-new age drivel, but more than likely harmful because she's causing false hopes.
Yes, of course. But as long as people think that it's national governments, or even Soros, Gates, Schwab, etc., they're lost. Those are all merely the pawns (governments generally speaking) and field officers. They're not the directors.
I see no hope in an earthly sense, only a spiritual one for those that rely on Christ from the heart.
People today are way too self-absorbed, ultimately not interested much less open to hearing much less believing the truth. (AKA, they can't handle the truth) Largely due the incessant and never-ending indoctrination.
It's funny, because I can prove the cognitive dissonance in the average person that thinks that they know what's going on, quite simply in fact, right here, anywhere really, and very simply using 2nd-grade math and a few simple statistics that can even accurately be obtained from "enemey" sources. In fact, that's where I got mine.
I was prescribed ivermectin for osteoarthritis a couple of years ago, and it seemed to help slowly. A friend suggested that fenbendazole seemed to help on her similar problems, so I tried that. It attacked the arthritis strongly, so I had to start with miniscule doses of fenben and work up. It also cleared out some rectal troubles.
The smallest doses were just topical application of little bit of fenbendazole goat dewormer. Still enough to cause plenty of immunopathology.
Not a fast fix, but flexibility is slowly and steadily returning.
Chris, how long did you take the ivermectin and at what dose before you saw improvement with your arthritis? I tried it for about ten days and saw no change in my lower back pain so I stopped. How much did the fenben help and at what dose? Thanks!
The ivermectin started at 18mg a week, eventually daily. The fenben at maybe 20mg, worked up to 224mg a week, then up to daily. I added the fenben to the ivermectin schedule, never did fenben alone. It took months for the fenben, not days. Both are back to weekly, which is likely to be forever considering the current psychopathic medical environment.
Daily back relief provided by inversion table, almost as good as a trip to the chiro.
Ok, some background. I had a long history with autoimmune, sarcoid, IBS, eye trouble, diabetes (f'ing prednisone!), and osteo. I found the marshallprotocol, which uses olmesartan medoximil as immunomodulator, and a series of antibiotics to cure what is always a group of infections in autoimmune. Once the immune system fails, you always get a bunch of co-infections.
Each and every antibiotic caused dramatic immunopathology for a while.
Antibiotics worked for some, but wasn't a complete fix for many. Replacing the antibiotics with just ivermectin was the next step, likely due to having antiviral properties. That helped more to a cure. But for me and others adding fenben to the ivermectin fixed yet more problems.
I'd been given a couple of rounds of antibiotics for the early sarcoid fevers. They did nothing. But after letting the olmesartan work for a month or so, even trivial doses of minocycline (25mg) were potent at first. Since I'd had the sarcoid for at least 20 years, I'd worked up quite the infectious load.
The whole damn process has been near 20 years for me, but that's because I'm an early guinea pig, and was damn sick when I started. I think it would have been a lot quicker if I'd started with iver & fenben & olmesartan.
Went from lifting 10 gallons of water, coaching volleyball and basketball, to caregiving at night and retail during the day, to who knows what will be working today.
I'm in my second year of R/A.
Hard to say why it happened.
Surgery in 2018, lost pints of blood, gallbladder explosion rocks tore up my insides. They also found a cancer tumor in my kidney, which explained why I was tired.
So. I have had tons of infections, anemia, and was finally feeling pretty good 2019 then caught a flu in January 2020. By Feb, my fingers were hurting so bad, I knew it wasn't regular arthritis.
My primary drs just kept blowing me off. Weren't listening, whatever.
2022. Officially diagnosed.
Changed diet, added every vitamin.
And off course was offered every r/a drug, that made me feel worse, if that was possible.
One, I broke out in hives and dr says, can't you just deal with it?
No. The others made me sleepy 24/7.
I tried and then just forget it. Did lots of fasting and detoxing, which is probably what has helped, but I need food for fuel, now.
Use lots of tape and they gave me meloxicam for pain. Joke. And prednisone. Come to find out they are the termites, that eat away inside.
Meloxicam is a NSAID.
Starting IVM. But sounds like I should be adding the dazzle too.
I was too chicken to try this at first, but as I'm getting weaker and it's spreading.
Going to have to go all out now.
Thank you. So not 10 days, more like a month. Plus.
A suggestion. The goat dewormer form of dazzle is easier to microdose. Dazzle is also more potent transdermally than oral. Or, at least it is for me. In all things auto-immune, your mileage will vary. The olmesartan used by the MP helps control the herx reaction.
to follow up ... our doc suggested using menbendazole in place of fenben, he thinks it a bit safer. Turns out the co-pay would be on the order of $5000. That's not missing a period, it is Five Thousand dollars!
His worry is that fenben in the amounts listed for Tippen Protocol is hard on the kidneys, and suggests 100mg as weekly dose. Which might be fine for prophylactic.
It’s looking promising for M.S. demyelination & easing motor symptoms. It has been looked at for awhile. I would much rather take this than inject who knows what into my body, with possible side effect of PML. Side effects of Ivermectin with normal dosage? Nada. Pretty exciting. 🏆👏🏼
The evidence and fact pattern suggests that those in power want to harm us or kill us. But what are some ways for us to fight back? Because unless there is a growing resistance movement that takes real action to put the fear of God into these people, things will only get worse. Voting harder isn't going to do it. What to do?
I found a similar outcome on my Heberden's nodes (red, painful, gnarly bumps supposedly from arthritis which had started a couple of years before), when I started taking Sunday-Sunday medicine (HCQ) back at the end of 2020 through '21. I suddenly realized, "Hey, my knuckles don't hurt anymore and the newer red bumps not only went away, but the lumps left from previous 'outbreaks' went way down. So, I tried an experiment and stopped taking regularly the HCQ after about a year or so and I'll be damned if a couple of months later I noticed my first knuckles started acting up again, getting red bumps. I will take HCQ as long as I can get it.
Thank you Donnah for posting your experiences. I was about to ask this very question. I have these nodes and they are getting worse. I have arthritis (osteoarthritis, ) in various joints, (back, neck, legs, hands ) and I'm very curious if either HCQ or IVM would be beneficial. Only problem is, I am in Italy and I really have no idea how I would get the stuff ☹
fluoride has a huge impact on bones causing major arthritis issues and osteoporosis etc. Borax / Boron can actually alleviate this and give the bones a chance to repair; obviously no fluoride in the water would be ideal but if you live in ireland, US , australia or New "Zealand chances are you'll have heart issues, lung problems, brain fog and arthritis, knee problems and hips etc. It's just what they like to do. Fascinating post!!! Well done -
Thank you for the deep dive on IVM. It is scary when you take a serious look at the many symptoms one might have that could be eliminated by IVM, etc. Biggest problem as a lay person is finding "trustworthy" practitioners that can assist with diagnosis, dosing and care in general. Might you, along with the wealth of knowledge you have already shared, have a list of such trusted practitioners? A solid referral could make all the difference in quality of life decisions for many.
Hi Mike, I wasn’t sure if I responded to you. I would follow FLCCC protocol & get Ivermectin online. I believe FLCCC can also refer you to a dr. if you’re more comfortable with that. Ivermectin is very safe with appropriate dosing. Some studies with very high dose ( CDC), showed side effects. These studies were ridiculous and more than anyone would take.
This is another great dr. speaking about it. Dr. Pierre Kory is excellent resource, if not the best. “ War on Ivermectin”
Thank you for the reply and information. I follow Zerospin and have dr. Korey's book. I ordered IVM through the link to Virex. 2 weeks, no response. Contacted customer service also no reply.
You will hear back & get your products. That’s who I used without issue. I would keep trying to contact. Sometimes they run out for awhile but mostly dependable. Remember to follow FLCCC protocol. Zinc is good with it.
I am seeing a slight connection (chemically) between Nattokinase and Ivermectin; they are both related to/derived from naturally occuring earthen bacteria. I would add all the yogurt bacillus in this frame, the earth knows what to do to keep its animals healthy.
Yes, Ann Barnhardt has reported that one of her followers has found ivermectin highly effective against arthritis, by taking just one ( I think low dose) pill per day...That person also reported that it had prevented colds and other minor health problems, which has been my experience too....
Hydroxychloroquine a.k.a Plaquenil which is an auto-immune suppressant - arthritis is caused by an overactive auto-immune system hence it helping which is why it's prescribed - so that's a bit misleading.
Although I'm a firm believer many alleged auto-immune diseases are in fact underlying infections (activating the auto-immune system) hence why Ivermectin would certainly address and possibly even help.
I wish I knew where you could purchase it from a reputable source - everything I've seen seems to come from abroad
Look into FOOD GRADE D.E. "Diatomaceous Earth". Routinely used in pet food. It kills parasites internally and externally.
Humans Also Consume This!
It's used to control pests in vegetation, plants, vegetable gardens, homesteads etc..If you have an ant, roach, bedbug, etc problem. They need not eat it only crawl over it and it slices there exoskeleton, they dehydrate and die. Just don't breathe in the fine powder as it's toxic to the lungs.
Many substance are simultaneously beneficial yet harmful. It reminds me of the delicate balance that is nature and life. Yin Yang. I wouldn't worry. They sell applicators to carefully spread around. Outdoors less of an issue. You just don't want a fan circulating in a room you've just treated with it. And this is an instance where a respirator mask would actually be justified. Ha!
I actually contacted Senator Casey (D-PA) because I was concerned that one of my meds from the VA came from China. Label was still on the bottle indicating facility and city.
I wanted his office to find out from the VA why they were purchasing meds made in China for veterans.
On 27 March 2023, I received a blow-off letter from Senator Casey's office saying they would "look into it."
Contacted Senator Casey's office again on 14 June 2023 inquiring about the status and whether or not they received an answer from the VA.
No response from Senator Casey's office. Whoever is supposed to handle Military and Veterans Affairs is not doing their job.
- ALL OF THIS IS USED ROUTINELY IN INDIA, MEXICO, CANADA, ETC.!!
THESE DRUGS ARE HIGHLY EFFECTIVE WHOLE BODY ANTI-PARASITICS , -- HISTORICALLY DELEGATED TO VETERINARIANS , WHO HAVE ALWAYS USED THEM EXTENSIVELY FOR BOTH ANIMALS, & HUMANS !!
Hmmmm...I have recurring De Quervain's Tenosynovitis. Severe. Excruciating.
I can only have so many cortisone shots and they're not great for you anyway. Surgery is my next option but I don't want to go that route really. I am now very leary of ANY needle wielding docs now too, so....
I wonder if it would help? It's basically inflammation of the two tendons running from the thumb to the wrist.
Also, I'm in Canada and ran into a problem trying to order. Haven't contacted them yet as it advised. Is it worth my time? Or will they tell me "sorry"....?
Good! I've used it for years without any problems. There are highly specialized MDs who administer intravenously too. The Israeli military uses it to treat brain swelling from concussions. Apparently, nothing works as quickly and as effectively in that traumatic setting. It goes on and on. Big Phama cannot patent it and it's too easily made available and inexpensively. So there's that.
Sounds like a familiar theme.
But not everyone responds to its anti-pain, anti--inflammatory effects. So, keep this in mind. Results may vary.
Ivermectin is highly effective against bedbugs, capable of eradicating or preventing bedbug infestations. When bedbugs bite a person that takes ivermectin-the bedbugs die.
Treatment for Endotoxemia
Ivermectin may inhibit lipopolysaccharide induced inflammation production of inflammatory cytokines by blocking NF-kB pathway and improve LPS-induced survival in mice. This finding might provide a new strategy for the treatment of endotoxemia and associated inflammation. Ivermectin improved mouse survival rate induced by a lethal dose of LPS. In addition, ivermectin significantly decreased the production of TNF-α, IL-1ß and IL-6 in vivo and in vitro. Furthermore, ivermectin suppressed NF-kB translocation induced by LPS.
NeurologicalDisorders/ Multiple Sclerosis
Many neurological disorders, such as motor neurone disease, arise due to cell death initiated by excessive levels of excitation in central nervous system neurons. A proposed novel therapy for these disorders involves silencing excessive neuronal activity using ivermectin. Because of its action on P2X4 receptors, ivermectin has potential with respect to preventing alcohol use disorders as well as for motor neurone disease. Indeed, in 2007, Belgian scientists applied for a patent, ‘Use of ivermectin and derivates thereof for the treatment of amyotrophic lateral sclerosis’ (Publication No.: WO/2008/034202A3), to cover ‘the use of ivermectin and analogs, to prevent, retard and ameliorate a motor neuron disease such as amyotrophic lateral sclerosis and the associated motor neuron degeneration. An anti-parasitic agent showed a potential to prevent inflammation and to promote nerve cell recovery — remyelination — in a mouse model of multiple sclerosis (MS). By promoting the activity of a receptor called P2X4R that is present in microglial cells — immune cells that reside in the brain — ivermectin (marketed as Stromectol, or Soolantra) eased the clinical manifestations of experimental autoimmune encephalomyelitis (EAE; an induced autoimmune disease similar to MS in humans).
Specifically, researchers saw evidence suggesting that ivermectin was “a potential candidate among currently used drugs to promote the repair of myelin damage,” they wrote. Their discovery was reported in the study “P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis,” published in the journal EMBO Molecular Medicine.
Antibacterial Properties
In 2012, reports emerged that ivermectin was capable of preventing infection of epithelial cells by the bacterial pathogen Chlamydia trachomatis, and to do so at doses that could be used to counter sexually transmitted or ocular infections. In 2013, researchers confirmed that ivermectin was bactericidal against a range of mycobacterial organisms, including multidrug resistant and extensively drug-resistant strains of Mycobacterium tuberculosis, the authors suggesting that ivermectin could be re-purposed for tuberculosis treatment. Although other researchers found that ivermectin does not possess anti-tuberculosis activity, the results were later shown to be non-comparable due to differences in testing methods, with the original findings being confirmed by further work in Japan. Ivermectin was also reported to be bactericidal against M. ulcerans.
Malaria
Ivermectin is being considered for mass drug administration for malaria, due to its ability to kill mosquitoes feeding on recently treated individuals. In a recent trial, 3-day courses of 300 and 600 mcg/kg/day were shown to kill Anopheles mosquitoes for at least 28 days post-treatment when fed patients’ venous blood using membrane feeding assays.
Frequently repeated mass administrations of ivermectin during the malaria transmission season can reduce malaria episodes among children without significantly increasing harms in the populace.
Rosacea/Scabies
Ivermectin is safe, easier to use, cheaper, more effective, and more economical than topicals in widespread institutional scabies, for those nonadherent to topicals, and in crusted scabies. Ivermectin is used ‘off-label’ to treat diseases associated with Demodex mites, such as blepharitis and demodicosis, oral ivermectin, in combination with topical permethrin, being a safe and effective treatment for severe demodicosis. Demodex mites have also been linked to rosacea, a chronic skin condition that manifests as recurrent inflammatory lesions. Long-term treatment is required to control symptoms and disease progression, with topical medicaments being the first-line choice. Ivermectin 1% cream is a new once-daily topical treatment for rosacea lesions, more effective and safer than all current options.
Asthma & Hypoxia
A 2011 study investigated the impact of ivermectin on allergic asthma symptoms in mice and found that ivermectin (at 2 mg kg−1) significantly curtailed recruitment of immune cells, production of cytokines in the bronchoalveolar lavage fluids and secretion of ovalbumin-specific IgE and IgG1 in the serum. Ivermectin also suppressed mucus hypersecretion by goblet cells, establishing that ivermectin can effectively curb inflammation, such that it may be useful in treating allergic asthma and other inflammatory airway diseases. Hypoxia-inducible transcription factors (HIFs) regulate hundreds of genes involved in cellular adaptation to reduced oxygen availability. HIFs consist of an O2-labile α-subunit (primarily HIF-1α and HIF-2α) and a constitutive HIF-1β subunit. In normoxia the HIF-α subunit is hydroxylated by members of a family of prolyl-4-hydroxylase domain (PHD) proteins, PHD1-3, resulting in recognition by von Hippel-Lindau protein, ubiquitination and proteasomal degradation. In contrast, reduced oxygen availability inhibits PHD activity resulting in HIF-1α stabilisation and nuclear accumulation. Nuclear import of HIF-1α mainly depends on classical nuclear localisation signals (NLS) and involves importin α/β heterodimers. Recently, a specific inhibitor of nuclear import has been identified that inhibits importin α/β-dependent import with no effects on a range of other nuclear transport pathways involving members of the importin protein family. In this study we evaluated the physiological activity of this importin α/β-inhibitor (Ivermectin) in the hypoxia response pathway. Treatment with Ivermectin decreases binding activity of HIF-1α to the importin α/β-heterodimer. Moreover, HIF-1α nuclear localisation, nuclear HIF-1α protein levels, HIF-target gene expression, as well as HIF-transcriptional activity are reduced upon Ivermectin treatment. For the first time, we demonstrate the effect of specific importin α/β-inhibition on the hypoxic response on the molecular level.
Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work is to examine the molecular mechanisms and functional roles of FXR modulation by avermectin analogues in regulating metabolic syndromes like NAFLD. We found that among avermectin analogues studied, the analogues that can bind and activate FXR are effective in regulating metabolic parameters tested, including reducing hepatic lipid accumulation, lowering serum cholesterol and glucose levels, and improving insulin sensitivity, in a FXR dependent manner. Mechanistically, the avermectin analogues that interact with FXR exhibited features as partial agonists, with distinctive properties in modulating coregulator recruitment. Structural features critical for avermectin analogues to selectively bind to FXR were also revealed. This study indicated that in addition to antiparasitic activity, avermectin analogues are promising drug candidates to treat metabolism syndrome including NAFLD by directly targeting FXR. Additionally, the structural features that discriminate the selective binding of FXR by avermectin analogues may provide a unique safe approach to design drugs targeting FXR signaling. ivermectin decreased the serum glucose and cholesterol levels in diabetic mice, by binding and activating nuclear receptor FXR with high affinity and selectivity. Interestingly, the potency of avermectin analogues in regulating metabolism correlates with their FXR binding capabilities and only the analogues that can bind and activate FXR reduced fat accumulation in mice liver. Consistent with its effects in regulating glucose and cholesterol, ivermectin treatment effectively reduced fat accumulation in diabetic mice.
I just recently started taking Petmectin 1 day on / 1 day off. My intention is to ward off the impending bio-attack on the population this Autumn 2023. However, now I'll be extra attentive to see if I benefit from its anti-inflammatory effects. Namely for osteoarthritis and tendinosis.
I think it does have positive anti inflammatory effects on my joints. I'm taking way less collagen, cucurmin, MSM, chondroiton, Hylauronic acid, glucosamine. Although I have been increasing my Omega 3 it alone could not be responsible. I attribute the IVM. However, I'm now only taking once per week.
Edit: accidentally mistyped p52 instead of p53 protein. Apologies.
I’m not a doctor. I’m a brain tumor survivor. This is just my personal observation and lay opinion, so please don’t come after me. Aren’t most forms of disease related to or caused by parasites and fungus? I was having this conversation with my neurosurgeon recently and he even said that there maybe be a correlation between tumors and parasites as well as fungus as it pertains to the cause of the brain tumor I had. I had the brain tumor successfully removed 4 and a half years ago. The way ivermectin has been demonized by the FDA, government officials, MSM and others, it’s my firm belief that ivermectin maybe one of the most effective treatments that we have to combat the diseases that we are experiencing
Ivermectin appears to be the most generally effective drug in the world, and it's a generic thanks to the generosity of its inventor...That's why Pharma hates it....
Headaches often due to gut issues like constipation or over toxicity - as in if you go off tea / caffeine and body starts gettng rid of the toxins, they build up and you get headaches unless you take a cup of tea........
magnesium deficiency also linked to headaches
Unless you are of Mediterranean lineage in which Aspirin can induce hemolytic anemia.
I spoke to a new friend about this. He's had a glioblastoma for years. One of his dogs is covered in lumps, the other has digestive issues, needs to be fed pumpkin for constipation. Each can be caused by parasites. I suggested he try ivermectin alone or with fenbendazole. What does he have to lose? His little buddy in his head? Unfortunately he's trapped by his faith. Faith that somehow the allopathic doctors that haven't helped him yet eventually will. And that if his faith slips, if he tries an alternative treatment, he'll have sinned against the Almighty MD's.
Both my parents died of cancer, a year apart, 23 years ago. I can't help but wonder, was it parasites from the small house dogs they had later in life? Would Ivermectin have saved them? I'll never know, but I suspect we will all learn of successful home treatment and cures of cancer in the near future, through association and word of mouth anyway.
Allopathic procedures are necessary in emergency situations, but for the most part I steer clear of hospitals and allopathic medicine. I have the good fortune of working with a phenomenal naturopathic care provider
How did you find the naturopathic care provider?
Looking for one on Cape Cod, but not sure how to separate the wheat from the chaff. Any advice would be greatly appreciated.
Look for a chiropractor who should be able to help you find a naturopathic or holistic practitioner
Maybe your friend would read some of these articles? Many of the comments on the Fen Ben Substack have great info too.
https://fenbendazole.substack.com/p/case-report-diffuse-midline-glioma
https://fenbendazole.s3.amazonaws.com/A-Cure-for-Cancer-Hidden-in-Plain-Sight-July-2019-Dr-David-Williams.pdf
https://fenbendazole.substack.com/p/mebendazole-fenbendazole-proposed
https://fenbendazole.substack.com/p/case-report-canine-lymphoma
https://www.nature.com/articles/s41598-018-30158-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526400/
Many tumours have been found to be sacs of parasite eggs; and even MS is parasites. Diabetes caused by fluke parasite which lives on insulin; go to the GP they'll feed the parasites and never deal with the issue; Dr June Levy proved these points above
This is an interesting discussion on parasites.
https://rumble.com/v2co4ra-banks-collapsing-market-failure-total-shitshow-ryan-dawson.html
We must all stick together and do not comply!
https://www.youtube.com/watch?v=LWRfWr65rlg
I'm starting to think that this threat of masking and more Injections is just that, an empty threat, to keep people focused on that while other far more damaging things go on.
Remember, always watch the Other Hand of the Magician.
If the world knew for a fact, that 9-11 and Lahaina were both conducted, wilfully, by the same ilk, how would Americans respond?
But we don't get it.
New vaxxines coming out on 9/11...........
New Injections are going to be coming out continually.
"Covid" (for those gullible enough to even think that it's real) is the first virus in human history that can only be cured by a never-ending string of government approved Injections.
Among the reasons why anyone with basis research skills could easily identify that this was a PSYOP starting the day it was hatched, is because of A, the status of the "vaccine" INDUSTRY, and B, the deaths, ill-health, disease, ailments, et al. that vaccines have caused over the decades.
Similar for Lahaina, we've seen a similar operation before, it was called 9-11, but how many people recognize that that too was a PSYOP and a deliberately played card by the exact same people bringing us this full-fledged demonization of the world today.
It doesn't get more sick bringing out the new shots to commemorate 9/11, on the same date.......seriously doesn't
Especially with Lahaina, aka 9-11 Hawaiian Version, going on.
They're out in the open now, no doubt laughing their heads off behind closed doors as to how they can come straight out and put their intentions out there and online, fully open for anyone to see, and see that the vast majority of people still don't have a clue.
SMH
I'm not sure about most people not having a clue any more though; it's massively different to what it was even a few months ago; HUGE awakeniing; although evenone prob sick and tired of that word, it's really happening and frankly their arrogance, especially with Winfrey coming out lookiing for donations for God's sake, completely ignorant of the fact they're just opening the trap door for themselves - it's going to get mad, definitely as the worm turns and they writhe and twist, but we just have to hold on and know God is there, with Russia, Africa and China, and Nature, to briing a final close to satan's vile wrretched foul debacle after the last hundred years war
Everything is absolutely fascinating to watch unfold. Those behind it all are playing the public like a master violinist plays a Stradivarius. It truly is masterful to behold. I find myself SMH perpetually at how well it all works for them, all but seemlessly. Meanwhile, we're tinkering with "yesterday's news."
PS ... my thought is that lockdowns won't happen for that reason. That could very well be part of their play. Get everyone hyped on that, everyone gets ready to dodge that "right cross," but then they get blind-sided by the left hook.
These people behind this as so predictable if one knows what to look for, and it's not difficult. But first people have to know who's really behind it.
Those looking to politics for the reasons, causes, solutions in particular, are entirely lost. Their hope of ever figuring it out are slim.
I've lost so much hope from most of the writers right here on Substack that I thought might actually realize what's going on at the core. I've been testing a few of them, but some of my comments are getting deleted by them. Which says much.
Caitlin Johnstone's the most recent. She's either bought and paid for, which makes sense given that she's supposedly operating out of Austrailia given how badly they've cracked down on so many others down there for much less, or she's simply lost as well, to the point of not only being useless with her semi-new age drivel, but more than likely harmful because she's causing false hopes.
"But first people have to know who's really behind it. "
Those who shall not be named?
Our masters?
Yes, of course. But as long as people think that it's national governments, or even Soros, Gates, Schwab, etc., they're lost. Those are all merely the pawns (governments generally speaking) and field officers. They're not the directors.
I see no hope in an earthly sense, only a spiritual one for those that rely on Christ from the heart.
People today are way too self-absorbed, ultimately not interested much less open to hearing much less believing the truth. (AKA, they can't handle the truth) Largely due the incessant and never-ending indoctrination.
It's funny, because I can prove the cognitive dissonance in the average person that thinks that they know what's going on, quite simply in fact, right here, anywhere really, and very simply using 2nd-grade math and a few simple statistics that can even accurately be obtained from "enemey" sources. In fact, that's where I got mine.
In short, it involves explaining how 3 - 6 = 5.
Most certainly, although I didn't comply last time either, but I see much more resistance from people this time...
I was prescribed ivermectin for osteoarthritis a couple of years ago, and it seemed to help slowly. A friend suggested that fenbendazole seemed to help on her similar problems, so I tried that. It attacked the arthritis strongly, so I had to start with miniscule doses of fenben and work up. It also cleared out some rectal troubles.
The smallest doses were just topical application of little bit of fenbendazole goat dewormer. Still enough to cause plenty of immunopathology.
Not a fast fix, but flexibility is slowly and steadily returning.
Chris, how long did you take the ivermectin and at what dose before you saw improvement with your arthritis? I tried it for about ten days and saw no change in my lower back pain so I stopped. How much did the fenben help and at what dose? Thanks!
The ivermectin started at 18mg a week, eventually daily. The fenben at maybe 20mg, worked up to 224mg a week, then up to daily. I added the fenben to the ivermectin schedule, never did fenben alone. It took months for the fenben, not days. Both are back to weekly, which is likely to be forever considering the current psychopathic medical environment.
Daily back relief provided by inversion table, almost as good as a trip to the chiro.
Ok, some background. I had a long history with autoimmune, sarcoid, IBS, eye trouble, diabetes (f'ing prednisone!), and osteo. I found the marshallprotocol, which uses olmesartan medoximil as immunomodulator, and a series of antibiotics to cure what is always a group of infections in autoimmune. Once the immune system fails, you always get a bunch of co-infections.
Each and every antibiotic caused dramatic immunopathology for a while.
Antibiotics worked for some, but wasn't a complete fix for many. Replacing the antibiotics with just ivermectin was the next step, likely due to having antiviral properties. That helped more to a cure. But for me and others adding fenben to the ivermectin fixed yet more problems.
I'd been given a couple of rounds of antibiotics for the early sarcoid fevers. They did nothing. But after letting the olmesartan work for a month or so, even trivial doses of minocycline (25mg) were potent at first. Since I'd had the sarcoid for at least 20 years, I'd worked up quite the infectious load.
The whole damn process has been near 20 years for me, but that's because I'm an early guinea pig, and was damn sick when I started. I think it would have been a lot quicker if I'd started with iver & fenben & olmesartan.
Chris, thank you for the info!
Wow, thank you for your post.
Went from lifting 10 gallons of water, coaching volleyball and basketball, to caregiving at night and retail during the day, to who knows what will be working today.
I'm in my second year of R/A.
Hard to say why it happened.
Surgery in 2018, lost pints of blood, gallbladder explosion rocks tore up my insides. They also found a cancer tumor in my kidney, which explained why I was tired.
So. I have had tons of infections, anemia, and was finally feeling pretty good 2019 then caught a flu in January 2020. By Feb, my fingers were hurting so bad, I knew it wasn't regular arthritis.
My primary drs just kept blowing me off. Weren't listening, whatever.
2022. Officially diagnosed.
Changed diet, added every vitamin.
And off course was offered every r/a drug, that made me feel worse, if that was possible.
One, I broke out in hives and dr says, can't you just deal with it?
No. The others made me sleepy 24/7.
I tried and then just forget it. Did lots of fasting and detoxing, which is probably what has helped, but I need food for fuel, now.
Use lots of tape and they gave me meloxicam for pain. Joke. And prednisone. Come to find out they are the termites, that eat away inside.
Meloxicam is a NSAID.
Starting IVM. But sounds like I should be adding the dazzle too.
I was too chicken to try this at first, but as I'm getting weaker and it's spreading.
Going to have to go all out now.
Thank you. So not 10 days, more like a month. Plus.
Topical castor oil helps.
A suggestion. The goat dewormer form of dazzle is easier to microdose. Dazzle is also more potent transdermally than oral. Or, at least it is for me. In all things auto-immune, your mileage will vary. The olmesartan used by the MP helps control the herx reaction.
Transdermal. On the skin or affected areas? I can do that. Thank you.
Thank you. I just started the ivm. Had some to start. Waiting for next order and the dazzle.
I know a great functional medicine dr.
Long story, but I am tired of arguing with spouse who wants me to go Kaiser drs, that did absolutely nothing but make everything worse.
Going back to the functional dr. Who had me watching these videos. Parasites and stuff. Didn't understand it at the time, but I do now.
He also used red light therapy for pain. Amazing. Boron spray too.
2+2=4
Kaiser just looked at me like I had 2 heads.
I'll share my story when I start seeing a difference.
to follow up ... our doc suggested using menbendazole in place of fenben, he thinks it a bit safer. Turns out the co-pay would be on the order of $5000. That's not missing a period, it is Five Thousand dollars!
His worry is that fenben in the amounts listed for Tippen Protocol is hard on the kidneys, and suggests 100mg as weekly dose. Which might be fine for prophylactic.
https://multiplesclerosisnewstoday.com/2018/07/13/anti-parasitic-agent-eases-ms-motor-symtoms-aid-remyelination-in-ms-mice/
It’s looking promising for M.S. demyelination & easing motor symptoms. It has been looked at for awhile. I would much rather take this than inject who knows what into my body, with possible side effect of PML. Side effects of Ivermectin with normal dosage? Nada. Pretty exciting. 🏆👏🏼
Excellent share!
Zero side effects at normal dose.
This may be of interest:
https://www.2ndsmartestguyintheworld.com/p/suicide-by-ivermectin-can-ingestion
Dr. Steven Phillips touches upon that. I cannot believe he doesn't have a wider audience!
https://zerospin.substack.com/p/ivermectin-upon-neutral-ground
Keep writing articles like this. You will have saved lives.
The evidence and fact pattern suggests that those in power want to harm us or kill us. But what are some ways for us to fight back? Because unless there is a growing resistance movement that takes real action to put the fear of God into these people, things will only get worse. Voting harder isn't going to do it. What to do?
Get healthy. Do NOT comply.
Y E S SSSSS !!!!!!
Yesss! 🔥 Seek and he shall find. Focus on healthful things, on any level of your being, i.e. body, mind, spirit - they are all interconnected.
I found a similar outcome on my Heberden's nodes (red, painful, gnarly bumps supposedly from arthritis which had started a couple of years before), when I started taking Sunday-Sunday medicine (HCQ) back at the end of 2020 through '21. I suddenly realized, "Hey, my knuckles don't hurt anymore and the newer red bumps not only went away, but the lumps left from previous 'outbreaks' went way down. So, I tried an experiment and stopped taking regularly the HCQ after about a year or so and I'll be damned if a couple of months later I noticed my first knuckles started acting up again, getting red bumps. I will take HCQ as long as I can get it.
Thank you Donnah for posting your experiences. I was about to ask this very question. I have these nodes and they are getting worse. I have arthritis (osteoarthritis, ) in various joints, (back, neck, legs, hands ) and I'm very curious if either HCQ or IVM would be beneficial. Only problem is, I am in Italy and I really have no idea how I would get the stuff ☹
Can you order it? Or is Italy banning the use of it? If you have friends that travel, many countries sell it. Good luck!
Is there a “PetHCQ” available?
Perhaps there's a "Petroxychloroquine" in the making?
Donnah, what dosage are you taking ?
It's the 200mg tablet once a week (Sunday). I am surprised that the weekly dosage has brought me relief.
Donnah, thanks for the reply. I’m only taking 12mg/day an am feeling great. Thanks and God Bless !!
Orley, I am talking about HCQ, you realize? It sounds like you are referring to an Ivermectin dosage.
fluoride has a huge impact on bones causing major arthritis issues and osteoporosis etc. Borax / Boron can actually alleviate this and give the bones a chance to repair; obviously no fluoride in the water would be ideal but if you live in ireland, US , australia or New "Zealand chances are you'll have heart issues, lung problems, brain fog and arthritis, knee problems and hips etc. It's just what they like to do. Fascinating post!!! Well done -
How do you take borax? I've always read it's poisonous.
Boron is the supplemental form. It comes in very low dosages.
Thank you for the deep dive on IVM. It is scary when you take a serious look at the many symptoms one might have that could be eliminated by IVM, etc. Biggest problem as a lay person is finding "trustworthy" practitioners that can assist with diagnosis, dosing and care in general. Might you, along with the wealth of knowledge you have already shared, have a list of such trusted practitioners? A solid referral could make all the difference in quality of life decisions for many.
Dr. Steven Phillips is a moral and conscientious MD within the Substackosphere.
I found this helpful you may as well:
https://zerospin.substack.com/p/ivermectin-upon-neutral-ground
Thank you for this! I am already on a deep dive into this information
Best of luck!
Hi Mike, I wasn’t sure if I responded to you. I would follow FLCCC protocol & get Ivermectin online. I believe FLCCC can also refer you to a dr. if you’re more comfortable with that. Ivermectin is very safe with appropriate dosing. Some studies with very high dose ( CDC), showed side effects. These studies were ridiculous and more than anyone would take.
This is another great dr. speaking about it. Dr. Pierre Kory is excellent resource, if not the best. “ War on Ivermectin”
https://zerospin.substack.com/p/ivermectin-upon-neutral-ground
Take care!
Thank you for the reply and information. I follow Zerospin and have dr. Korey's book. I ordered IVM through the link to Virex. 2 weeks, no response. Contacted customer service also no reply.
Mike
You will hear back & get your products. That’s who I used without issue. I would keep trying to contact. Sometimes they run out for awhile but mostly dependable. Remember to follow FLCCC protocol. Zinc is good with it.
Take care- let me know when you get it.
I am seeing a slight connection (chemically) between Nattokinase and Ivermectin; they are both related to/derived from naturally occuring earthen bacteria. I would add all the yogurt bacillus in this frame, the earth knows what to do to keep its animals healthy.
Yes, Ann Barnhardt has reported that one of her followers has found ivermectin highly effective against arthritis, by taking just one ( I think low dose) pill per day...That person also reported that it had prevented colds and other minor health problems, which has been my experience too....
Hydroxychloroquine a.k.a Plaquenil which is an auto-immune suppressant - arthritis is caused by an overactive auto-immune system hence it helping which is why it's prescribed - so that's a bit misleading.
Although I'm a firm believer many alleged auto-immune diseases are in fact underlying infections (activating the auto-immune system) hence why Ivermectin would certainly address and possibly even help.
I wish I knew where you could purchase it from a reputable source - everything I've seen seems to come from abroad
From Florida, USA: https://www.virex.health/index.php?route=product/product&product_id=53
Isn't that for pets only?
Look into FOOD GRADE D.E. "Diatomaceous Earth". Routinely used in pet food. It kills parasites internally and externally.
Humans Also Consume This!
It's used to control pests in vegetation, plants, vegetable gardens, homesteads etc..If you have an ant, roach, bedbug, etc problem. They need not eat it only crawl over it and it slices there exoskeleton, they dehydrate and die. Just don't breathe in the fine powder as it's toxic to the lungs.
Cheers!
I actually use this on my dog all the time as I will not use any chemicals! Thanks again!! Didn't know about the dust toxicity though - now I worry!!
Many substance are simultaneously beneficial yet harmful. It reminds me of the delicate balance that is nature and life. Yin Yang. I wouldn't worry. They sell applicators to carefully spread around. Outdoors less of an issue. You just don't want a fan circulating in a room you've just treated with it. And this is an instance where a respirator mask would actually be justified. Ha!
Virex may be in Florida, but where is their petmectin made?
The same facility that manufactures for Merck.
All inquiries should be sent to: info@virex.health
So do my blood pressure meds that the VA sends me.
Just received a new BP med and the original label is still on the bottle...it was made in Bangladesh.
is that considered good or bad
I wouldn't eat canned vegetables if they came from Bangladesh.
So...I worry where my Rx drugs come from.
Most Rx comes from India and China. Around 98%.
I actually contacted Senator Casey (D-PA) because I was concerned that one of my meds from the VA came from China. Label was still on the bottle indicating facility and city.
I wanted his office to find out from the VA why they were purchasing meds made in China for veterans.
On 27 March 2023, I received a blow-off letter from Senator Casey's office saying they would "look into it."
Contacted Senator Casey's office again on 14 June 2023 inquiring about the status and whether or not they received an answer from the VA.
No response from Senator Casey's office. Whoever is supposed to handle Military and Veterans Affairs is not doing their job.
No one will help you.
This is how the Medical Industrial Complex works.
At some point China stops exporting meds to the USA, and it is all over.
There is currently an Adderral shortage ahead of the school year, which may be a good thing actually.
The Indians have the highest quality meds. You may not eat a can of their tik masala, but you are ingesting their pharmaceuticals along with China's.
You expected a dumbocrap to care where meds came from?
- ALL OF THIS IS USED ROUTINELY IN INDIA, MEXICO, CANADA, ETC.!!
THESE DRUGS ARE HIGHLY EFFECTIVE WHOLE BODY ANTI-PARASITICS , -- HISTORICALLY DELEGATED TO VETERINARIANS , WHO HAVE ALWAYS USED THEM EXTENSIVELY FOR BOTH ANIMALS, & HUMANS !!
Hmmmm...I have recurring De Quervain's Tenosynovitis. Severe. Excruciating.
I can only have so many cortisone shots and they're not great for you anyway. Surgery is my next option but I don't want to go that route really. I am now very leary of ANY needle wielding docs now too, so....
I wonder if it would help? It's basically inflammation of the two tendons running from the thumb to the wrist.
It should in theory help any pet with De Quervain's Tenosynovitis.
Ahhh yes. Did I say *I* have De Quervain's? Typo.
My dog! 😏
It wouldn't surprise me if YOU did have it. I did. Luckily, the cortisone shot took care of it.
Edited for the ubiquitous typo.
Also, I'm in Canada and ran into a problem trying to order. Haven't contacted them yet as it advised. Is it worth my time? Or will they tell me "sorry"....?
- NO.
?
No what?
And human.
You're not getting 2sg's comment 😉
I belived the data shows Petmectrin and Petbendazole helps humans too.
-- ABSOLUTELY ...!!!
Have you ever looked into topical DMSO as a pain releaver?
No I've been reading about it online though! I will likely give it a try.
Amandah Dawn Vollmer has some articles here on Substack as well!
Good! I've used it for years without any problems. There are highly specialized MDs who administer intravenously too. The Israeli military uses it to treat brain swelling from concussions. Apparently, nothing works as quickly and as effectively in that traumatic setting. It goes on and on. Big Phama cannot patent it and it's too easily made available and inexpensively. So there's that.
Sounds like a familiar theme.
But not everyone responds to its anti-pain, anti--inflammatory effects. So, keep this in mind. Results may vary.
60 Minutes Episode back in the day:
https://www.youtube.com/watch?v=4XEt0n6LPrk
Thanks!❤️
Some more possible benefits of using Ivermectin:
Bedbugs
Ivermectin is highly effective against bedbugs, capable of eradicating or preventing bedbug infestations. When bedbugs bite a person that takes ivermectin-the bedbugs die.
Treatment for Endotoxemia
Ivermectin may inhibit lipopolysaccharide induced inflammation production of inflammatory cytokines by blocking NF-kB pathway and improve LPS-induced survival in mice. This finding might provide a new strategy for the treatment of endotoxemia and associated inflammation. Ivermectin improved mouse survival rate induced by a lethal dose of LPS. In addition, ivermectin significantly decreased the production of TNF-α, IL-1ß and IL-6 in vivo and in vitro. Furthermore, ivermectin suppressed NF-kB translocation induced by LPS.
NeurologicalDisorders/ Multiple Sclerosis
Many neurological disorders, such as motor neurone disease, arise due to cell death initiated by excessive levels of excitation in central nervous system neurons. A proposed novel therapy for these disorders involves silencing excessive neuronal activity using ivermectin. Because of its action on P2X4 receptors, ivermectin has potential with respect to preventing alcohol use disorders as well as for motor neurone disease. Indeed, in 2007, Belgian scientists applied for a patent, ‘Use of ivermectin and derivates thereof for the treatment of amyotrophic lateral sclerosis’ (Publication No.: WO/2008/034202A3), to cover ‘the use of ivermectin and analogs, to prevent, retard and ameliorate a motor neuron disease such as amyotrophic lateral sclerosis and the associated motor neuron degeneration. An anti-parasitic agent showed a potential to prevent inflammation and to promote nerve cell recovery — remyelination — in a mouse model of multiple sclerosis (MS). By promoting the activity of a receptor called P2X4R that is present in microglial cells — immune cells that reside in the brain — ivermectin (marketed as Stromectol, or Soolantra) eased the clinical manifestations of experimental autoimmune encephalomyelitis (EAE; an induced autoimmune disease similar to MS in humans).
Specifically, researchers saw evidence suggesting that ivermectin was “a potential candidate among currently used drugs to promote the repair of myelin damage,” they wrote. Their discovery was reported in the study “P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis,” published in the journal EMBO Molecular Medicine.
Antibacterial Properties
In 2012, reports emerged that ivermectin was capable of preventing infection of epithelial cells by the bacterial pathogen Chlamydia trachomatis, and to do so at doses that could be used to counter sexually transmitted or ocular infections. In 2013, researchers confirmed that ivermectin was bactericidal against a range of mycobacterial organisms, including multidrug resistant and extensively drug-resistant strains of Mycobacterium tuberculosis, the authors suggesting that ivermectin could be re-purposed for tuberculosis treatment. Although other researchers found that ivermectin does not possess anti-tuberculosis activity, the results were later shown to be non-comparable due to differences in testing methods, with the original findings being confirmed by further work in Japan. Ivermectin was also reported to be bactericidal against M. ulcerans.
Malaria
Ivermectin is being considered for mass drug administration for malaria, due to its ability to kill mosquitoes feeding on recently treated individuals. In a recent trial, 3-day courses of 300 and 600 mcg/kg/day were shown to kill Anopheles mosquitoes for at least 28 days post-treatment when fed patients’ venous blood using membrane feeding assays.
Frequently repeated mass administrations of ivermectin during the malaria transmission season can reduce malaria episodes among children without significantly increasing harms in the populace.
Rosacea/Scabies
Ivermectin is safe, easier to use, cheaper, more effective, and more economical than topicals in widespread institutional scabies, for those nonadherent to topicals, and in crusted scabies. Ivermectin is used ‘off-label’ to treat diseases associated with Demodex mites, such as blepharitis and demodicosis, oral ivermectin, in combination with topical permethrin, being a safe and effective treatment for severe demodicosis. Demodex mites have also been linked to rosacea, a chronic skin condition that manifests as recurrent inflammatory lesions. Long-term treatment is required to control symptoms and disease progression, with topical medicaments being the first-line choice. Ivermectin 1% cream is a new once-daily topical treatment for rosacea lesions, more effective and safer than all current options.
Asthma & Hypoxia
A 2011 study investigated the impact of ivermectin on allergic asthma symptoms in mice and found that ivermectin (at 2 mg kg−1) significantly curtailed recruitment of immune cells, production of cytokines in the bronchoalveolar lavage fluids and secretion of ovalbumin-specific IgE and IgG1 in the serum. Ivermectin also suppressed mucus hypersecretion by goblet cells, establishing that ivermectin can effectively curb inflammation, such that it may be useful in treating allergic asthma and other inflammatory airway diseases. Hypoxia-inducible transcription factors (HIFs) regulate hundreds of genes involved in cellular adaptation to reduced oxygen availability. HIFs consist of an O2-labile α-subunit (primarily HIF-1α and HIF-2α) and a constitutive HIF-1β subunit. In normoxia the HIF-α subunit is hydroxylated by members of a family of prolyl-4-hydroxylase domain (PHD) proteins, PHD1-3, resulting in recognition by von Hippel-Lindau protein, ubiquitination and proteasomal degradation. In contrast, reduced oxygen availability inhibits PHD activity resulting in HIF-1α stabilisation and nuclear accumulation. Nuclear import of HIF-1α mainly depends on classical nuclear localisation signals (NLS) and involves importin α/β heterodimers. Recently, a specific inhibitor of nuclear import has been identified that inhibits importin α/β-dependent import with no effects on a range of other nuclear transport pathways involving members of the importin protein family. In this study we evaluated the physiological activity of this importin α/β-inhibitor (Ivermectin) in the hypoxia response pathway. Treatment with Ivermectin decreases binding activity of HIF-1α to the importin α/β-heterodimer. Moreover, HIF-1α nuclear localisation, nuclear HIF-1α protein levels, HIF-target gene expression, as well as HIF-transcriptional activity are reduced upon Ivermectin treatment. For the first time, we demonstrate the effect of specific importin α/β-inhibition on the hypoxic response on the molecular level.
Ivermectin & Metabolic Diseases/Non-Alcoholic Fatty Liver Disease/Insulin Resistance/Diabetes/
Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work is to examine the molecular mechanisms and functional roles of FXR modulation by avermectin analogues in regulating metabolic syndromes like NAFLD. We found that among avermectin analogues studied, the analogues that can bind and activate FXR are effective in regulating metabolic parameters tested, including reducing hepatic lipid accumulation, lowering serum cholesterol and glucose levels, and improving insulin sensitivity, in a FXR dependent manner. Mechanistically, the avermectin analogues that interact with FXR exhibited features as partial agonists, with distinctive properties in modulating coregulator recruitment. Structural features critical for avermectin analogues to selectively bind to FXR were also revealed. This study indicated that in addition to antiparasitic activity, avermectin analogues are promising drug candidates to treat metabolism syndrome including NAFLD by directly targeting FXR. Additionally, the structural features that discriminate the selective binding of FXR by avermectin analogues may provide a unique safe approach to design drugs targeting FXR signaling. ivermectin decreased the serum glucose and cholesterol levels in diabetic mice, by binding and activating nuclear receptor FXR with high affinity and selectivity. Interestingly, the potency of avermectin analogues in regulating metabolism correlates with their FXR binding capabilities and only the analogues that can bind and activate FXR reduced fat accumulation in mice liver. Consistent with its effects in regulating glucose and cholesterol, ivermectin treatment effectively reduced fat accumulation in diabetic mice.
https://www.nature.com/articles/ja201711
https://www.nature.com/articles/s41429-020-0336-z
https://pubmed.ncbi.nlm.nih.gov/26351913/?dopt=Abstract
https://www.degruyter.com/document/doi/10.1515/hsz-2015-0171/html
https://pubmed.ncbi.nlm.nih.gov/16410358/?dopt=Abstract
https://www.nature.com/articles/ncomms2924
https://www.nature.com/articles/srep17288
https://pubmed.ncbi.nlm.nih.gov/32998532/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008305/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751445/
https://pubmed.ncbi.nlm.nih.gov/16620226/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743833/
https://pubmed.ncbi.nlm.nih.gov/25911032/
https://academic.oup.com/ced/article-abstract/33/2/211/6624972
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(94)91625-X/fulltext
Ivermectin for spasticity in spinal-cord injury
JonathanL. Costa
JesusA. Diazgranados Published:March 19, 1994 DOI:https://doi.org/10.1016/S0140-6736(94)91625-X
https://link.springer.com/article/10.1007/s00011-008-8007-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446326/
https://pubmed.ncbi.nlm.nih.gov/21279416/?dopt=Abstract
I just recently started taking Petmectin 1 day on / 1 day off. My intention is to ward off the impending bio-attack on the population this Autumn 2023. However, now I'll be extra attentive to see if I benefit from its anti-inflammatory effects. Namely for osteoarthritis and tendinosis.
Any update on this, Purple? (Also don’t know why this reply keeps duplicating?!?)
Hey JudyC,
I think it does have positive anti inflammatory effects on my joints. I'm taking way less collagen, cucurmin, MSM, chondroiton, Hylauronic acid, glucosamine. Although I have been increasing my Omega 3 it alone could not be responsible. I attribute the IVM. However, I'm now only taking once per week.
Thanks for this info…really helpful! I’m going to give it a try!
Best of luck. Please keep us posted :)
Always!