The issue is around obtaining best (maximum) absorption. Some meds/supplements need fats for best absorption, some don’t. So, is there research that I am not readily finding that indicates which is best way for taking it. No doubt people around the world just toss it down however without problem, but are they getting maximum benefits.
The issue is around obtaining best (maximum) absorption. Some meds/supplements need fats for best absorption, some don’t. So, is there research that I am not readily finding that indicates which is best way for taking it. No doubt people around the world just toss it down however without problem, but are they getting maximum benefits.
I agree. I take my D with a meal containing fat. Plus others. I’ve just never seen this addressed with IVM and I have read ALOT about it. So clarification would be nice. Cheers.
I read some document (can't remember what/where) that if you take ivm with a fatty meal, you get 2.5x the absorbtion into your blood stream compared to taking it on an empty stomach. If you take it on an empty stomach, there is more left behind to do its work on your gut parasites. So WHY you take it dictates HOW you should take it.
Thanks! Makes sense that way too. I did recently run across this in a paper -
"the high lipid solubility of ivermectin resulting in it being widely distributed throughout the body. Following oral administration, mean peak plasma concentration occurs approximately 4 h after dosing, a second peak at 6–12 h probably arising because of enterohepatic recycling of the drug, with the plasma half-life of ivermectin being around 12 h"
The high lipid solubility certainly seems to suggest taking with a meal
The issue is around obtaining best (maximum) absorption. Some meds/supplements need fats for best absorption, some don’t. So, is there research that I am not readily finding that indicates which is best way for taking it. No doubt people around the world just toss it down however without problem, but are they getting maximum benefits.
Ben Fen had a good post on this. Taken with butter, olive oil or peanut butter is best for absorption
Rick, my bottle of pills says to take with food.
I agree. I take my D with a meal containing fat. Plus others. I’ve just never seen this addressed with IVM and I have read ALOT about it. So clarification would be nice. Cheers.
I suspect that it is slightly better to take it with at least a little food, true for most things....
I read some document (can't remember what/where) that if you take ivm with a fatty meal, you get 2.5x the absorbtion into your blood stream compared to taking it on an empty stomach. If you take it on an empty stomach, there is more left behind to do its work on your gut parasites. So WHY you take it dictates HOW you should take it.
Thanks! Makes sense that way too. I did recently run across this in a paper -
"the high lipid solubility of ivermectin resulting in it being widely distributed throughout the body. Following oral administration, mean peak plasma concentration occurs approximately 4 h after dosing, a second peak at 6–12 h probably arising because of enterohepatic recycling of the drug, with the plasma half-life of ivermectin being around 12 h"
The high lipid solubility certainly seems to suggest taking with a meal