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Zelkova's avatar

Doesn't one of the B vitamins help with neuropathy? Maybe B3, I forget which one.

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The Great Resist's avatar

Try methylated B-complex.

My 62yo husband has had idiopathic neuropathy in his feet for years. He doesn’t have diabetes and his circulation has been tested and is fine, but he had unexplained nerve damage in his feet, and it was starting to appear in his hands. He could step barefoot in a puddle of cold water and not even feel it. He once stumped his foot against something while walking, only noticed because it made him stumble, but it didn’t cause pain. By that night, his big toe was black, and the nail eventually fell off.

Over the last year+, he has spent thousands of dollars on specialists trying to get a sore on his toe to heal, because since he couldn’t feel the toe, he couldn’t tell which shoes were making it worse or when the bandage had fallen off letting the sore keep rubbing and being torn open. (Gross!)

His wound care doctor recently recommended that he take a genetic test (available on Amazon) to check for a variant in the MTHFR gene, and he does have the variant that means his body is unable to properly methylate B vitamins, causing nerve damage. So he recently started taking a methylated B-complex supplement, and has had noticeable improvement in his neuropathy. (The supplement is all the B’s, not just B3, in methylated form.)

He complained just this morning about the cold tile floor in the bathroom - yay!!

My dad also has neuropathy, and recently started taking a prescription methylated vitamin supplement prescribed by his doctor, and he’s also noticing improvement.

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Feb 2, 2024
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The Great Resist's avatar

I ordered it from Amazon. My husband’s doctor didn’t recommend any particular brand so I just searched for methylated B-complex and decided on one from Igennus described as “Super B-Complex – Methylated Sustained Release Clean Label B Complex with Methylfolate, Boosted B12 Methylcobalamin…”

The one my dad takes is a prescription called “Elfolate Plu 3-35-2MG

Generic.’L-Methylfolate w/ Vit B6-Vi…” I think it’s pricey at some pharmacies but reasonable at others.

The gene test was from Amazon. It was “empowerDX at Home MTHFR gene test.” It wasn’t covered by insurance, but it was eligible for FSA (flex-spending) or HSA funds.

Best wishes to you for healing! I’ve seen firsthand how frustrating and debilitating neuropathy is, especially when highly-regarded specialists run all kinds of expensive tests, then just shrug their shoulders and say “Beats me.”

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